The micro capillary Protein Crystallization System™ or the Plug Maker™ is a next-generation protein crystallization workstation that enables you to obtain crystals from as little as 10nL of protein per experiment. Perform high-throughput, batch-style crystallization in "plugs" inside microfluidic CrystalCards™. The crystals can be easily extracted for analyis by X-ray diffraction or subjected to in situ x-ray diffraction.
- Screen, optimize, and produce diffraction ready crystal
- Generate up to 800 individual experiments per CrystalCard using about 4 μL of protein
- Combine protein with up to 24 conditions at a range of concentrations in each CrystalCard
- Increase your chance of obtaining a high quality crystal
Grow crystals in durable, x-ray transmissive CrystalCards. Visualize crystallization sweet spots, transport crystals, or store them for months in the cards. Remove crystals easily for traditional cryoprotection and x-ray diffraction studies. Or test crystals for x-ray diffraction inside the CrystalCards using a simple goniometer adapter.
These images show actual crystals grown in, and harvested from, CrystalCards along with the correspoding 3-D structures that resulted
Each CrystalCard combines protein, precipitant, and buffer to create individual experiments at various concentrations that are separated by carrier fluid. Ideal for sparse matrix and gradient screening, ligand screening, microfluidic seeding, batch-style protein crystallization experiments, and simultaneous gradient screening from two crystallization hits.