The micro capillary Protein Crystallization System™, also known as the Plug Maker™, is a cutting-edge protein crystallization workstation designed to help you obtain crystals using as little as 10nL of protein per experiment. This system allows for high-throughput, batch-style crystallization within microfluidic CrystalCards™, making it easy to extract crystals for analysis through X-ray diffraction or in situ X-ray diffraction.
With the ability to screen, optimize, and produce diffraction-ready crystals, you can generate up to 800 individual experiments per CrystalCard using only about 4 μL of protein. Each CrystalCard can combine protein with up to 24 different conditions at varying concentrations, significantly increasing your chances of obtaining high-quality crystals.
Grow crystals in durable, x-ray transmissive microfluidic CrystalCards. Visualize crystallization sweet spots, transport crystals, or store them for months in these innovative cards. Easily remove crystals for traditional cryoprotection and x-ray diffraction studies. Alternatively, you can test crystals for x-ray diffraction inside the microfluidic CrystalCards using a simple goniometer adapter. Enhance your protein crystallization system with our Plug Maker to streamline the process further.
These images showcase actual crystals that were grown in and harvested from microfluidic CrystalCards, along with the corresponding 3-D structures that emerged from our advanced protein crystallization system and Plug Maker.
Each microfluidic CrystalCard combines protein, precipitant, and buffer to create individual experiments at various concentrations that are separated by carrier fluid. This system is ideal for sparse matrix and gradient screening, ligand screening, microfluidic seeding, batch-style protein crystallization experiments, and simultaneous gradient screening from two crystallization hits using the Plug Maker.